Figure 3: Metformin diminishes inflammatory cell accumulation in the kidneys with cisplatin-induced AKI. | Scientific Reports

Figure 3: Metformin diminishes inflammatory cell accumulation in the kidneys with cisplatin-induced AKI.

From: Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

Figure 3

(A) Representative micrographs showing the immuno-staining images for Ly6b and F4/80 among different groups. Arrows indicate Ly6b or F4/80 staining positive cells. Bar = 50 μm. (B) Quantitative determination of Ly6b-positive cells within kidney tissues among different groups. *P < 0.05 compared to vehicle control (n = 3 − 5); #P < 0.05 compared to mice treated with cisplatin alone (n = 5). (C) Quantitative determination of F4/80-positive cells within kidney tissues among different groups. *P < 0.05 compared to vehicle control (n = 3 − 5); #P < 0.05 compared to mice treated with cisplatin alone (n = 5).

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