Figure 5: Adh mediates IL-8 release through the activation of the MAPK signaling pathway. | Scientific Reports

Figure 5: Adh mediates IL-8 release through the activation of the MAPK signaling pathway.

From: Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release

Figure 5

(A) Activation of MAPK in A. pleuropneumoniae 5b WT- or 5b ΔAdh-infected PAMs; (B–E) The effects of pretreatment with SP600125, PD98059, PDTC, or SB203580 on IL-8 release in A. pleuropneumoniae 5b WT- or 5b ΔAdh-infected PAMs; (F) The effects of pretreatment with SB203580 on the expression of IL-8 mRNA in 5b WT- or 5b ΔAdh-infected PAMs; (G) The effects of pretreatment with SB203580 on the recruitment of neutrophils in 5b WT- or 5b ΔAdh-infected PAMs.

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