Figure 7: HIV-1 protease inhibitors block HIV-1 recovery from latently infected J-Lat 8.4 cells. | Scientific Reports

Figure 7: HIV-1 protease inhibitors block HIV-1 recovery from latently infected J-Lat 8.4 cells.

From: Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

Figure 7

(A–C), J-Lat cells were either left untreated or treated with anti-CD3-mAb (2 μg/ml) +rNef (100 ng/ml) (A), anti-CD28-mAb (2.67 μg/ml) +anti-CD3-mAb (2 μg/ml) (B) and SAHA (2.5 μM) (C) in the absence or presence of different PI and RTI compounds as indicated. The viral production was determined by measuring the level of p24 antigen using ELISA. Means ± s.d. (n = 6). Ctr: Control; L/R, lopinavir/ritonavir; ATV: atazanavir; FOS: fosamprenavir, ABC: abacavir; EFV: efavirenz.

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