Figure 2
From: The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
The effect of OTX015 on reactivation of latent HIV-1 is potently enhanced in combination with prostratin.
C11 cells were mock-treated or treated with either OTX015 (0.01 μM), prostratin (0.2 μM), or OTX015 (0.01 μM)/prostratin (0.2 μM). The effect of activation of the HIV-1 promoter was determined by quantifying GFP-positive cells 48 hours after treatment using flow cytometry. A summary of the activation assays is presented as a series of histograms.
