Figure 2: HCCR silencing significantly decreased the resistance of HGC-27-R cells to 5-FU. | Scientific Reports

Figure 2: HCCR silencing significantly decreased the resistance of HGC-27-R cells to 5-FU.

From: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3

Figure 2

(A) The western blot and qPCR detection of HCCR expression in HGC-27-R cells stably transfected with a negative control or 3 different HCCR-shRNAs. *P < 0.001. (B,C) FCM analysis of the 5-FU-induced rate of apoptosis in HGC-27-R cells transfected with control shRNA or HCCR-shRNA1. Cells in the media were treated with progressive concentrations of 5-FU (0.0, 5.0 or 10.0 μg/mL) for 24 h before the FCM assay. All results are shown as the means (±s.d.) of three separate experiments, *P < 0.01.

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