Figure 3: HCCR silencing inhibited cell growth and induced apoptosis by modulating the expression of p-STAT3. | Scientific Reports

Figure 3: HCCR silencing inhibited cell growth and induced apoptosis by modulating the expression of p-STAT3.

From: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3

Figure 3

Protein expression was determined by western blot assay, cell proliferation was assayed by the MTT method, and apoptosis was assayed by FCM. (A) Parental gastric cancer cells (red) and negative control cells (pink) showed more growth than HCCR-shRNA1-transduced cell clones (navy, light blue or green). *P < 0.001. Apoptosis in parental cells was significantly lower than in HCCR-shRNA1-transduced cells. *P < 0.001. (B) The proliferation of HCCR1-cDNA-transduced AGS cells (navy or light blue) was significantly higher than that of parental cells (red) and negative control cells (pink) *P < 0.001. Apoptosis in HCCR1-cDNA-transduced cells was significantly lower than in parental cells, *P < 0.001.

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