Figure 4: The 5-FU-induced apoptosis modulated by HCCR expression was dependent on STAT3 activity. | Scientific Reports

Figure 4: The 5-FU-induced apoptosis modulated by HCCR expression was dependent on STAT3 activity.

From: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3

Figure 4

HCCR-shRNA/HCCR1-cDNA-transduced AGS cells were treated with IL-6, a STAT3 inhibitor (S3I-201), and 5-FU (10.0 μg/mL) for 24 h. Cell apoptosis was determined by FCM assay. HCCR, p-STAT3, cleaved caspase-3 and PARP levels were assayed by western blot. The results are shown as the means (±s.d.) of three separate experiments, *P < 0.05.

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