Figure 5
The neuroprotection effect of DNCB, TrxR1 AS-ODNs and TAT-AVPY against injury in rat hippocampal CA1 regions induced by I/R.
(A) Cresyl violet staining was performed on sections of rat hippocampi subjected to sham operation (a and b), five days of reperfusion after global ischemia (c and d), or pretreatment with TAT-AVPY (e and f), DNCB (i and j), TrxR1 AS-ODNs (m and n), TAT-MMLL (g and h), DMSO (k and l), or TrxR1 MS-ODNs (o and p). The boxed areas in the left column are shown at higher magnification in the right columns. Original magnification ×40 in panels a, c, e, g, i, k, m and o; and ×400 in panels b, d, f, h, j, l, n and p. Scale bars: 200 μm (panels a, c, e, g, i, k, m and o) and 10 μm (panels b, d, f, h, j, l, n and p). (B) The cell density was expressed as the number of cells per 1 mM length of the CA1 pyramidal cells counted under a light microscope. Data were the mean ± S.D. (n = 6). *P < 0.05 vs. the sham group, #P < 0.05 vs. the R5d group.
