Figure 1: Effects of WCUP on body weight, tumor growth, and food intake in CT-26 tumor-bearing mice. | Scientific Reports

Figure 1: Effects of WCUP on body weight, tumor growth, and food intake in CT-26 tumor-bearing mice.

From: Citrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma

Figure 1

Male BALB/c mice (n = 15) were subcutaneously injected with CT-26 cells in the abdominal region. On day 10 after tumor inoculation, the mice were divided randomly into three groups (n = 5 per group) and administered WCUP daily at doses of 250 and 500 mg/kg, or saline for 17 days. Control mice with no tumors (n = 5) were also administered an equal volume of saline daily during the experiment. Body weight (A), food intake (B), and tumor volume (C) were compared on days 14, 17, 20, 24, and 27. At the time of sacrifice, tumors were removed and weighed (D). Animal experiments were repeated three times, and representative results are shown. Data are presented as means ± SD. Statistical significance was determined with Student t-test. *p < 0.05, significantly different from the group of ‘tumor + saline’ in the same day (on day 17; tumor + WCUP 250 mg/kg, p = 0.0210, tumor + WCUP 500 mg/kg, p = 0.0234) (on day 20; tumor + WCUP 250 mg/kg, p = 0.0123, tumor + WCUP 500 mg/kg, p = 0.0193) (on day 24; tumor + WCUP 250 mg/kg, p = 0.0258).

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