Figure 7: Impact of the frequency of mechanical stress f−1 on hMSC proliferation. | Scientific Reports

Figure 7: Impact of the frequency of mechanical stress f−1 on hMSC proliferation.

From: Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency

Figure 7

(a–d) Dual staining with DAPI (blue) and anti-BrdU (magenta) of hMSCs (t = 20 d) experiencing: (a) no change (Type A), (b) f−1 = 10 d (Type C), (c) f−1 = 2 d. (d) hMSCs cultured on plastic dishes (control). (e) Fractions of anti-BrdU positive (proliferating) cells χ plotted as function of duration of a mechanical step f−1 at t = 10 d (blue) and 20 d (red) exhibiting a non-linear relationship between χ and f−1. Each data point represents mean values ± SD for n > 30 cells.

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