Table 2 HSP expression in TETs and ITMIG recommended outcome measures.

From: HSP27 and 70 expression in thymic epithelial tumors and benign thymic alterations: diagnostic, prognostic and physiologic implications

ITMIG recommended

outcome measures

HSP expression in TETs

Cytoplasmic HSP27

Cytoplasmic HSP70

Nuclear HSP70

Overall Survival (OS)

weak

(n = 5)

mod/str

(n = 90)

weak

(n = 15)

mod/str

(n = 80)

weak

(n = 10)

mod/str

(n = 85)

1 year

100%

100%

100%

100%

100%

100%

5 year

100%

96.3%

93.3%

97.2%

100%

96.1%

10 year

66.7%

92%

81.7%

92.4%

87.5%

91.4%

p-value a

0.867

0.377

0.980

Cancer Specific

Survival (CSS)

weak

mod/str

weak

mod/str

weak

mod/str

1 year

100%

100%

100%

100%

100%

100%

5 year

100%

97.7%

93.3%

98.7%

100%

97.6%

10 year

66.7%

95.6%

81.7%

96.4%

87.5%

95.3%

p-value a

0.352

0.291

0.985

Freedom From

Recurrence (FFR)

weak

mod/str

weak

mod/str

weak

mod/str

1 year

100%

100%

100%

100%

100%

100%

5 year

60%

95.3%

72%

97.1%

60%

97.5%

10 year

60%

92%

72%

93.3%

60%

93.9%

p-value a

0.017

0.082

0.016

  1. TETs with absent or weak cytoplasmic HSP27 and nuclear HSP70 staining showed significantly worse FFR. There was no significant difference for OS and CSS. ITMIG , International Thymic Malignancy Interest Group; HSP , Heat Shock Protein; TETs , Thymic Epithelial Tumors; OS , Overall Survival; CSS , Cancer Specific Survival; FFR , Freedom From Recurrence; n, number; mod/str, moderate to strong HSP expression.
  2. aLog-rank test.