Table 1 In vitro antimicrobial activities of compounds 1–8.
From: Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens
Compounds | Minimum inhibitory concentrations ( μ g/mL) | |||||
|---|---|---|---|---|---|---|
Gram-negative | Gram-positive | |||||
E. coli ATCC 35218 | E. coli ATCC 25922 | P. aeruginosa ATCC 27853 | K. pneumoniae ATCC 700603 | S. aureus ATCC 43300 | E. faecalis ATCC 29212 | |
1 | 8.52 | 8.52 | 68.16 | ≥100 | ≥100 | 68.16 |
2 | 4.26 | 2.13 | 17.04 | ≥100 | 34.08 | 4.26 |
3 | 4.26 | 2.13 | 17.04 | ≥100 | 34.08 | 17.04 |
4 | 17.04 | 17.04 | ≥100 | 34.08 | ≥100 | ≥100 |
5 | 17.04 | 8.52 | ≥100 | 68.16 | ≥100 | 68.16 |
6 | 8.52 | 4.26 | 34.08 | ≥100 | 34.08 | 17.04 |
7 | 8.52 | 8.52 | 34.08 | ≥100 | 68.16 | 17.04 |
8 | 17.04 | 17.04 | ≥100 | 68.16 | ≥100 | ≥100 |
Amikacin | 4.26 | 2.13 | 2.13 | 8.52 | – | – |
Ceftriaxone | 8.52 | 2.13 | 2.13 | 2.13 | – | – |
Vancomycin | – | – | – | – | 0.53 | 0.53 |
