Table 3 Binding affinity and inhibitory activities of screened compounds 1–8.

From: Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens

Compound

Dissociation constant with E. coli FabI

Inhibitory activities against E. coli FabI

Kda ( μ M)

IC50( μ M)

1

b n.i.

110.1

2

215.0 ± 28.8

2.7

3

270.0 ± 9.1

3.0

4

b n.i.

110.7

5

b n.i.

c n.i.

6

289.0 ± 31.1

52.1

7

329.0 ± 29.7

71.8

8

b n.i.

c n.i.

Triclosan

11.4 ± 8.3

0.77

  1. aThe Kd value is automatic calculated by the curve fitting, and presents as means ± SD for three experiments.
  2. bn.i. is no clear binding detected in the MST measurement.
  3. cn.i. is no inhibition detected in the experiments (IC50 > 1 mM).
Back to article page