Figure 8: Working model for the activities of IL-20 and 7E in osteogenesis.

(a) A schematic representation showing that IL-20 is an inhibitory factor for osteoblastogenesis and promotes osteoclastogenesis. (b) Blocking of IL-20 by anti-IL-20 mAb (7E) caused the increased osteoblastogenesis and the inhibited osteoclastogenesis.