Table 1 Calculated dissociation constants (KD).

From: Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4

Receptor

Ligand

KD(M)

Purified TLR4 extracellular domain

CnB

3.7 × 10−7

Purified soluble CD14

CnB

1.01 × 10−6

Soluble MD2 in culture supernatant

CnB

7.4 × 10−5

TLR4-GFP in 293 lysates

CnB

6.5 × 10−6

CD14-GFP in 293 lysates

CnB

3.48 × 10−5

MD2-GFP in 293 lysates

CnB

7.43 × 10−6