Figure 1
From: Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons
SST rapidly silences GHRH neuron activity.
(A) Representative trace showing silencing of an identified GHRH neuron following local pressure ejection of somatostatin (SST). (B) Mean effects of SST treatment on spontaneous action potential firing (top) and resting potential amplitude (bottom) in GHRH neurons from male animals (n = 7). Data are averages of 2 sec bins. Statistically significant differences versus control (before SST application) are highlighted by the white area (P < 0.05, paired Student’s t test). (C) 5 min SST exposure induced an outward current in a GHRH neuron held at −50 mV. (D) Mean SST-induced current densities in GHRH neurons at the onset (peak) and end (late) of 1 μM SST ejections. Males are shown in blue and females in red. (E) As for (D) but mean decay rates of the SST-induced current densities.
