Figure 3
From: Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice
Sgp130 reduces DEN-induced inflammatory responses in mouse liver tissue at 16 weeks.
(a) Schematic diagrams of sgp130 in inhibiting IL-6 signaling. (b) Expression of p-STAT3, IL-6, IL-6R and gp130 in mouse liver tissue (400×). (A: Control; B: model group; C: sgp130 treatment group). (c) sgp130 changes the DEN-induced high level of liver related factors in mouse sera. (d) B-ultrasonography of liver for detecting DEN-induced hepatic fibrosis (Arrowheads point to hepatic fibrosis bright spots or stripes; (A: Control; B: model group; C: sgp130 treatment group)). (e) type IV collagen expressed in tissue of mouse livers, detected with immunohistochemical staining (400×) (A: Control; B: model group; C: sgp130 treatment group).
