Figure 4: Ultrastructure of synaptic endings under TEM. | Scientific Reports

Figure 4: Ultrastructure of synaptic endings under TEM.

From: Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS

Figure 4

(a–e) Synaptic ultrastructure of rats from the saline group (n = 3 rats). (f–j) Synapses of rats in the acute treatment group (n = 3 rats) contained a greater number of presynaptic vesicles (white arrows) than the other three groups. (k–o) Synapses of rats in the chronic treatment group (n = 3 rats) had more presynaptic vesicles (white arrows) in the inferior colliculus (IC), auditory cortex (AC), hippocampus (HP) and amygdala (AMY). There were greater PSDs (black arrows), longer synaptic active zones in the IC and AC, and increased synaptic interface curvature in the IC, AC and HP compared with the saline and wash-out (n = 3 rats) groups. No significant ultrastructural changes were observed in the cerebellum (CRB). (p–t) Synaptic ultrastructure of rats from the wash-out group; there were no significant differences observed between the saline and wash-out groups. Scale bar, 0.2 μm.

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