Table 1 Comparisons of synaptic parameters among different groups.

From: Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS

Area

N = 18

Saline

Acute

Chronic

Wash-out

IC

Synaptic vesicles (number/μm2)

18 ± 7

130 ± 31**

60 ± 25**

20 ± 7

Cleft width (nm)

17.42 ± 3.29

19.71 ± 5.68

16.99 ± 5.62

19.29 ± 2.06

PSD thickness (nm)

22.38 ± 9.37

29.12 ± 7.37

41.24 ± 9.44**

27.94 ± 5.41

Synaptic curvature

1.07 ± 0.01

1.04 ± 0.02

1.10 ± 0.04*

1.05 ± 0.03

Length of synaptic active zone (nm)

338.73 ± 25.99

303.08 ± 73.12

504.19 ± 91.40**

334.96 ± 83.01

Synaptic vesicles (number/μm2)

18 ± 8

94 ± 27**

50 ± 13**

17 ± 4

Cleft width (nm)

15.51 ± 2.07

20.15 ± 4.20

16.47 ± 3.26

20.11 ± 4.11

AC

PSD thickness (nm)

29.18 ± 6.81

31.13 ± 4.81

38.70 ± 8.68*

27.67 ± 6.01

Synaptic curvature

1.04 ± 0.04

1.08 ± 0.02

1.14 ± 0.06*

1.05 ± 0.04

Length of synaptic active zone (nm)

279.52 ± 57.04

297.86 ± 44.72

400.07 ± 97.15**

314.56 ± 57.36

Synaptic vesicles (number/μm2)

17 ± 6

68 ± 24**

37 ± 13**

13 ± 3

Cleft width (nm)

18.95 ± 2.76

18.33 ± 3.31

16.50 ± 3.34

18.95 ± 2.81

HP

PSD thickness (nm)

34.22 ± 5.67

29.43 ± 7.46

33.25 ± 5.51

38.88 ± 9.67

Synaptic curvature

1.05 ± 0.03

1.07 ± 0.02

1.14 ± 0.04*

1.05 ± 0.03

Length of synaptic active zone (nm)

240.81 ± 64.02

231.98 ± 75.29

272.53 ± 56.78

244.99 ± 42.69

Synaptic vesicles (number/μm2)

16 ± 4

64 ± 10**

27 ± 7**

14 ± 3

Cleft width (nm)

19.13 ± 2.04

18.33 ± 3.79

17.53 ± 2.63

18.49 ± 2.81

AMY

PSD thickness (nm)

28.81 ± 7.33

26.18 ± 7.61

33.93 ± 6.47

30.43 ± 5.10

Synaptic curvature

1.05 ± 0.03

1.06 ± 0.03

1.09 ± 0.03

1.06 ± 0.02

Length of synaptic active zone (nm)

337.69 ± 78.99

344.45 ± 99.20

356.13 ± 70.88

329.98 ± 68.91

Synaptic vesicles (number/μm2)

18 ± 5

71 ± 16**

23 ± 11

20 ± 6

Cleft width (nm)

19.02 ± 2.61

19.42 ± 3.52

17.47 ± 3.76

18.54 ± 2.43

CRB

PSD thickness (nm)

34.08 ± 5.68

32.82 ± 6.77

31.30 ± 5.00

30.71 ± 4.84

Synaptic curvature

1.05 ± 0.03

1.07 ± 0.04

1.07 ± 0.03

1.06 ± 0.02

Length of synaptic active zone (nm)

312.48 ± 100.84

317.34 ± 60.80

330.97 ± 61.58

302.98 ± 93.49

  1. N, number of photographs. Saline group (n = 3 rats), acute treatment group (n = 3 rats), chronic treatment group (n = 3 rats), wash-out group (n = 3 rats). Inferior colliculus (IC), auditory cortex (AC), hippocampus (HP), amygdala (AMY), and cerebellum (CRB). *p < 0.05 compared with saline group; **p < 0.01 compared with saline group.
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