Figure 3 | Scientific Reports

Figure 3

From: Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight

Figure 3

Correlation of megalin and Dab2 abundance in brush border area of syncytiotrophoblast.

Correlation between amounts of Megalin and Dab2 was assessed using Spearman’s rank correlation coefficient (r). Megalin and Dab 2 abundance in all placentas (n = 28) was measured in arbitrary fluorescence units (AFU) using immunofluorescence assay as described in Methods. Six study participants (4 with PE and hemozoin, 1 with hemozoin only and 1 without PE or hemozoin) did not have detectable megalin and Dab2. Line indicates linear regression, slope = 0.77 + 0.19, p = 0.0003. PE – parasitized erythrocytes in the placenta at the time of delivery. Hemozoin in the placenta at the time of delivery is indicative of past infection.

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