Figure 7: Behavior changes of APPswe/PS1dE9 mice after treatment with Ago299-5p. | Scientific Reports

Figure 7: Behavior changes of APPswe/PS1dE9 mice after treatment with Ago299-5p.

From: MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity in APPswe/PS1dE9 mice

Figure 7

(a) In a contextual fear conditioning test, the freezing time for APPswe/PS1dE9 mice treated with Ago299-5p was higher than for Scr-miR-treated transgenic mice (Tg-ctr) or sham untreated mice (Tg-sham), both at 1 and 3 weeks after injection. (b) In the cued conditioning test, there was no significant difference between these five groups. The sound cue intervention is showed as dotted line. (c) In the MWM test, the escape latency to reach the hidden platform during the acquisition phase was determined over 5 days. (d) The percentage of time mice spent in the four quadrants during the probe trial of the MWM test. (e) Representative swimming trajectories in the probe trial. (f) Passing times in the probe trial. (g) The average swimming speed during the water maze training (mean ± SD, n = 5 per group, *p < 0.05 compared with control group, #represents no significance).

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