Figure 3: Dependence of antagonist potencies (IC50) on C5a concentration in human monocyte-derived macrophages. | Scientific Reports

Figure 3: Dependence of antagonist potencies (IC50) on C5a concentration in human monocyte-derived macrophages.

From: Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Figure 3

Inhibitory responses of antagonist (A) 3D53, (B) W54011 and (C) JJ47 against various concentrations of C5a (300 nM, ●; 100 nM, ■; 30 nM, ▲; 10 nM, ◆; 3 nM, ▼; 1 nM, ★) relative to C5a (300 nM) inducing calcium release in HMDM (100%). Calculated pIC50 ± SEM and IC50 values for the three C5aR antagonists are summarized in the table versus concentration of C5a. Error bars are means ± SEM of three independent experiments (n = 3).

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