Figure 6

MEF-induced cardiac pacing in an anesthetized pig.

(a) A photograph of the experimental setting. (b) IMPs (100 mg) were injected to the femoral vein while pulses were applied through the electromagnet (96 bpm). In this setting only sporadic events of pacing were noted, presumably since IMPs did not accumulate in the RV. (c) When IMPs (200 mg) were injected and allowed to accumulate in the RV for ~1 min by a DC current, overdrive MEF-based pacing was noted and maintained until the pulses were terminated due to overheating of the electromagnet. The blue line indicates the arterial pressure (AP) and the red line indicates the current through the electromagnet coil, which correlates with the magnetic induction generated by the electromagnet. Plus (+) signs indicate heart beats that are synchronized with the magnetic pulses.