Figure 2: DNAm and CGI status.
From: Gene-set Analysis with CGI Information for Differential DNA Methylation Profiling
(A) Boxplots of differences in DNAm between matched pairs of ovarian cancer patients (cases) and normal controls for 100 randomly selected probes. The 76 red boxplots are for probes in CGI region; while the 24 black boxplots are for probes not in CGI. Probes in CGI tend to have larger variation in θij, indicating a larger degree of variability in DNAm between cases and controls. (B) Correlation plots of θij. The upper left panel contains correlations of θij from probes not in CGI; while the lower right panel is for probes in CGI. The correlation in each panel is larger, as compared to the correlations in the other two blocks, indicating a greater degree of similarity in θij, the differences in DNAm.
