Table 1 Numbers are the posterior probability of γk>0 under the specified model for the UKOPS study.
From: Gene-set Analysis with CGI Information for Differential DNA Methylation Profiling
KEGG pathway term (no. of genes/no. of probes) | Constant effect model | Degree effect model | ||||
|---|---|---|---|---|---|---|
(b1) CGI- independent | (b2) CGI- dependent | (c1) CGI- independent | (c2) CGI- dependent | |||
Y | N | Y | N | |||
hsa05200 Pathways in cancer (303/714) | 0.01 | 0.02 | 0.03 | 0.19 | 0.10 | 0.35 |
hsa04110 Cell cycle (120/308) | 0.96 | 0.97 | 0.44 | 0.84 | 0.89 | 0.55 |
hsa04114 Oocyte meiosis (101/211) | 0.21 | 0.14 | 0.65 | 0.23 | 0.18 | 0.56 |
hsa00980 Metabolism of xenobiotics by cytochrome P450 (69/122) | 0.30 | 0.31 | 0.50 | 0.56 | 0.17 | 0.74 |
hsa00330 Arginine and proline metabolism (53/100) | 0.44 | 0.25 | 0.70 | 0.51 | 0.27 | 0.68 |
hsa04510 Focal adhesion (192/418) | 0.50 | 0.45 | 0.69 | 0.49 | 0.45 | 0.59 |
hsa04610 Complement and coagulation cascades (64/113) | 0.43 | 0.25 | 0.41 | 0.59 | 0.24 | 0.54 |
hsa00982 Drug metabolism - cytochrome P450 (63/111) | 0.62 | 0.46 | 0.47 | 0.41 | 0.66 | 0.28 |
hsa00350 Tyrosine metabolism (31/57) | 0.49 | 0.43 | 0.43 | 0.48 | 0.24 | 0.45 |
hsa04115 p53 signaling pathway (67/201) | 0.32 | 0.50 | 0.38 | 0.57 | 0.68 | 0.20 |
