Figure 2 | Scientific Reports

Figure 2

From: NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy

Figure 2

NLRP3 expression in human IgAN.

Immunofluorescence confocal microscopy in frozen sections of normal kidney tissue (obtained from a representative human nephrectomy sample) (a) or a representative kidney biopsy from a patient with IgAN (b). Dual labeling probing for NLRP3 (green) and PDGFR-β (red) or kidney injury molecule-1 (KIM-1, red); NLRP3 (red) with alpha smooth muscle actin (α-SMA, green). Nuclear stain using DAPI (blue) is shown in merged images. Magnified views of the indicated regions outlined from the merged images. Scale bars 100 μm. Arrows point to areas of yellow indicating colocalization of green and red channels. Images are representative of experiments performed at least 3 independent times.

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