Figure 8 | Scientific Reports

Figure 8

From: NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy

Figure 8

NLRP3 mRNA expression and renal outcome in IgAN.

(a) NLRP3 mRNA expression by quantitative real-time PCR in patients with IgAN. RNA isolated from renal biopsies of patients with IgAN grouped into quartiles (Q1–4) based on NLRP3 mRNA expression levels standardized to normal kidney samples. Values are normalized to endogenous 18S mRNA expression levels. (b) Hazard ratio for NLRP3 quartiles based on the multivariable Cox model for the composite outcome of doubling serum Cr, ESRD or death. There is a significant linear trend towards lower risk of composite outcome with higher levels of NLRP3 (p = 0.047). (c) Product-limit survival estimates from each quartile. Quartile 1: low NLRP3; quartile 2: low-intermediate; quartile 3: high-intermediate; and quartile 4: high NLRP3. NLRP3 mRNA expression was analyzed as a logarithmic variable due to its non-normal distribution and displayed as quartiles in a survival curve. (d) Correlation of NLRP3 mRNA expression with KIM-1 mRNA expression.

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