Table 2 Multivariable Cox model for the composite outcome of doubling of serum creatinine, ESRD, or death correlated to the pathologic features of the Oxford classification.

From: NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy

Predictors

Hazard ratio (95% CI)

p-value

Mesangial hypercellularity

5.90 (0.78, 44.44)

0.085

Endocapillary hypercellularity

1.29 (0.11, 15.26)

0.839

Segmental glomerulosclerosis

ND (0, –)

0.995

Tubular atrophy/interstitial fibrosis T1 (vs. T0)

1.73 (0.16, 18.59)

0.652

 T2 (vs. T0)

43.82 (2.61, 734.44)

0.01*

  1. T = tubular atrophy/interstitial fibrosis. T0 = 0–25%, T1 = 26–50%, T2 = >50%.
  2. *Indicates statistically significance p < 0.05. ND, not determined. Due to limitations of modeling, the hazard ratio for segmental sclerosis could not be determined since all biopsied samples had the presence of segmental glomerulosclerosis.
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