Figure 2: Cross-matching of sequencing data.
From: Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer
(a) Venn diagrams of the differentially-expressed genes cross-matched with the DMRs in their promoter and 5′UTR regions in the three comparison groups. Genes were chosen when their expression changes were negatively associated with changes in the DMRs in chemoresistant cells versus MCF-7/WT cells. (b) Venn diagrams of the differentially-expressed miRNAs cross-matched with DMRs around the miRNA coding sequence in the three comparison groups. (c) Up- or down-regulated miRNAs were integrated with the overall methylation level when comparing resistant with sensitive cells. Red bars, overall methylation levels (Y axis) of up-regulated miRNAs in MCF-7/ADM or /PTX versus /WT cells; green bars, overall methylation levels of down-regulated miRNAs in MCF-7/ADM or /PTX versus /WT cells. (d) Locations of the DMRs relative to the TSS of each miRNA. X axis, Log2 values of DMRs (resistant versus sensitive); Y axis, their locations relative to the TSS.
