Table 1 Genetic diversity of the founder and evolved populations determined by ultra-deep sequencing a,b .

From: Constrained evolvability of interferon suppression in an RNA virus

Line

Gene

SNP

Residue

Abundance (%)

Founder

L

G5899A

D105N

19.8

L

G7365A

22.7

L

A9498G

40.6

L

A9584U

E1333V

30.6

L

A10420C

I1612L

37.3

L

C11175U

37.0

L

G11217A

37.8

L1

P

A1898C

M168L

78.5

P

G1900A

M168I

17.5

P

A2019C

Q208P

65.7

P

U2077C

78.8

M

C2388A

18.6

G

C4119A

12.8

L

U7326A

14.3

L

C7624U

19.6

L

G9486A

14.2

L

G9591A

14.4

L

C10400A

S1605Y

19.6

L2

N

G543U

11.7

P

G1900A

M168I

86.0

M

A2472C

R73S

11.4

M

A2755G

K168E

46.2

G

A3716U

E210V

11.9

G

A4138C

I351L

12.6

L

G6148U

G188C

13.9

L

G6972A

11.2

L

U7050C

12.2

L

A7820G

E745G

13.5

L3

M

C2639U

P129L

49.3

L

G6188A

R201K

27.5

L

A6245G

K220R

14.9

L

A6963U

27.2

L

U10373A

M1596K

24.1

  1. aAll SNPs with >10% population frequency are shown except for the marker gene GFP. A full list of SNPs is provided in Supplementary Data S1.
  2. bChanges detected by Sanger sequencing are underlined.