Figure 7 | Scientific Reports

Figure 7

From: Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts

Figure 7

A schematic model of lncRNA-ATB functions in the pathogenesis of keloids.

TGF-β signaling activation regulates a variety of downstream genes including lncRNA-ATB, which sequesters miR-200c away from mRNA of ZNF217, leading to upregulaion of ZNF217 protein and TGF-β2 transcription. Then TGF-β2 binds to TGF-βR and actives TGF-β signaling pathway reversely and forms the LncRNA-ATB/miR-200c/ZNF217/TGF-β2 loop mediating skin fibrosis.

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