Table 1 The inhibitory activities of active bufadienolides on HGC-27 3D spheroids and 2D monolayer cells.
From: Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides
Compounds | 3D | 2D | |||||
|---|---|---|---|---|---|---|---|
IC501 (μM) | IC502 (μM) | IC503 (μM) | IC504 (μM) | IC505 (μM) | IC506 (μM) | IC50(μM) | |
No.1 | 0.002 ± 0.001 | 0.001 ± 0.0006 | 0.001 ± 0.0005 | 0.001 ± 0.0004 | 0.002 ± 0.0008 | 0.002 ± 0.0008 | 0.034 ± 0.005 |
No.2 | 0.013 ± 0.011 | 0.012 ± 0.007 | 0.015 ± 0.006 | 0.014 ± 0.005 | 0.017 ± 0.006 | 0.019 ± 0.005 | 0.087 ± 0.017 |
No.3 | 0.067 ± 0.044 | 0.058 ± 0.024 | 0.053 ± 0.02 | 0.058 ± 0.019 | 0.067 ± 0.019 | 0.078 ± 0.026 | 0.152 ± 0.019 |
No.5 | 0.067 ± 0.046 | 0.091 ± 0.045 | 0.085 ± 0.04 | 0.086 ± 0.034 | 0.096 ± 0.036 | 0.112 ± 0.041 | 0.285 ± 0.057 |
No.6 | – | 0.002 ± 0.001 | 0.003 ± 0.002 | 0.003 ± 0.001 | 0.003 ± 0.001 | 0.004 ± 0.001 | 0.014 ± 0.002 |
No.7 | 0.019 ± 0.013 | 0.029 ± 0.007 | 0.034 ± 0.01 | 0.041 ± 0.014 | 0.058 ± 0.015 | 0.073 ± 0.018 | 0.018 ± 0.003 |
No.8 | 0.144 ± 0.104 | 0.15 ± 0.082 | 0.154 ± 0.076 | 0.152 ± 0.065 | 0.178 ± 0.078 | 0.199 ± 0.082 | 1.044 ± 0.274 |
No.9 | 0.051 ± 0.043 | 0.064 ± 0.038 | 0.069 ± 0.033 | 0.079 ± 0.031 | 0.099 ± 0.038 | 0.116 ± 0.04 | 0.279 ± 0.062 |
Taxol | 1.683 ± 1.667 | 0.065 ± 0.044 | 0.069 ± 0.052 | 0.045 ± 0.031 | 0.064 ± 0.041 | 0.062 ± 0.031 | 0.275 ± 0.059 |
Epirubicin | 1.488 ± 1.27 | 0.34 ± 0.217 | 0.104 ± 0.045 | 0.064 ± 0.028 | 0.048 ± 0.022 | 0.036 ± 0.015 | 1.041 ± 0.146 |
