Table 2 Association of clinicopathological features with the overall tumour response after induction chemotherapy for the 399 patients with advanced stage NPC.
Characteristic | CR | PR | SD | P1 b | P2 b | P3 b |
|---|---|---|---|---|---|---|
No. (%) | No. (%) | No. (%) | ||||
Age (years) | 0.135 | 0.721 | 0.543 | |||
<50 | 76 (75.2) | 176 (67.2) | 26 (72.2) | |||
≥50 | 25 (24.8) | 86 (32.8) | 10 (27.8) | |||
Sex | 0.955 | 0.106 | 0.081 | |||
Male | 77 (76.2) | 199 (76.0) | 32 (88.9) | |||
Female | 24 (23.8) | 63 (24.0) | 4 (11.1) | |||
Smoking | 0.067 | 0.002 | 0.038 | |||
Yes | 30 (29.7) | 105 (40.1) | 21 (58.3) | |||
No | 71 (70.3) | 157 (59.9) | 15 (41.7) | |||
Drinking | 0.802 | 0.091 | 0.083 | |||
Yes | 11 (10.9) | 31 (11.8) | 8 (22.2) | |||
No | 90 (89.1) | 231 (88.2) | 28 (77.8) | |||
WHO pathology | ||||||
Type I | 0 (0) | 2 (0.8) | 0 (0) | 1.000 | - | 1.000 |
Type II/III | 101 (100) | 260 (99.2) | 36 (100) | |||
T categorya | 0.131 | 0.008 | 0.041 | |||
T1-2 | 27 (26.7) | 51 (19.5) | 2 (5.6) | |||
T3-4 | 74 (73.3) | 211 (80.5) | 34 (94.4) | |||
N categorya | 0.471 | 0.728 | 0.387 | |||
N0-1 | 65 (64.4) | 179 (68.3) | 22 (61.1) | |||
N2-3 | 36 (35.6) | 83 (31.7) | 14 (38.9) | |||
Overall stagea | 0.397 | 0.11 | 0.184 | |||
II | 16 (15.8) | 28 (10.7) | 1 (2.8) | |||
III | 42 (41.6) | 113 (43.1) | 19 (52.8) | |||
IVA-IVB | 43 (42.6) | 121 (46.2) | 16 (44.4) | |||
Concurrent chemotherapy | 0.761 | 0.619 | 0.737 | |||
Yes | 85 (84.2) | 217 (82.8) | 29 (80.6) | |||
No | 16 (15.8) | 45 (17.2) | 7 (19.4) | |||
Cycles of IC | 0.009 | <0.001 | 0.023 | |||
2 | 40 (39.6) | 144 (55.0) | 27 (75.0) | |||
≥3 | 61 (60.4) | 118 (45.0) | 9 (25.0) | |||
