Table 4 Multivariate analysis of prognostic factors associated with clinical outcomes based on the overall tumour responses after induction chemotherapy.

From: The Tumour Response to Induction Chemotherapy has Prognostic Value for Long-Term Survival Outcomes after Intensity-Modulated Radiation Therapy in Nasopharyngeal Carcinoma

Endpoint

Variable

P a

HR

95% CI for HR

DFS

Overall response, CR vs. PR

0.008

0.403

0.206–0.788

Overall response, SD vs. PR

0.005

2.288

1.289–4.061

OS

Overall response, CR vs. PR

0.024

0.301

0.106–0.853

Overall response, SD vs. PR

0.023

2.294

1.119–4.702

N category

0.003

2.431

1.357–4.353

DMFS

N category

<0.001

2.808

1.614–4.886

LRRFS

Overall response, CR vs. PR

0.032

0.319

0.112–0.904

Gender

0.015

2.240

1.173–4.278

  1. Abbreviations: DFS = disease-free survival; OS = overall survival; DMFS = distant metastases-free survival; LRRFS = locoregional relapse-free survival; HR = hazard ratio; CI = confidence interval; CR = complete response; PR = partial response; SD = stable disease.
  2. aMultivariate P-values were calculated using an adjusted Cox proportional-hazards model. The following parameters were included in the Cox proportional hazards model with backward elimination: age (≥50 y vs. <50 y), gender (male vs. female), smoking (yes vs. no), drinking (yes vs. no), pathological type (type I vs. type II/III), T category, N category, concurrent chemotherapy (yes vs. no), overall tumour response (CR vs. PR; SD vs. PR).
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