Figure 4
From: Microbial metabolite butyrate facilitates M2 macrophage polarization and function
Therapeutic effect of M2-BMDMs on DSS colitis.
DSS was administered to mice to induce colitis and M0 or M2-BMDMs were transferred intravenously. (a) Relative body weight change, (b) disease activity index and (c) colon length of mice with colitis, treated with M0 or M2 BMDMs or untreated (DSS) and control mice. (d) Histological appearance and histological scores of colons. (e) IL-1β, IL-6 and TNF-α in serum. (f) Quantitation of Arg1 protein expression in serial sections by immunohistochemistry. The mean IOD (IOD/total area) represents the Arg1 expression level. Data are representative of 6 mice/group, with similar staining. Data are shown as mean ± SD for three independent experiments, Comparisons between means used t tests (*P < 0.05, **P < 0.01, ***P < 0.001).
