Figure 1
From: Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells
Soluble FLT1 has a suppressive effect against cell proliferation and the effect is neutralized by VEGF.
(a) The number of cells transfected with pLV-EGFP or pLV-sFLT1 as well as with addition of VEGF. The number of cells was significantly lower in the sFLT1 group. *P < 0.05 compared to the pLV-EGFP group. (b) The number of cells transfected by pLV-EGFP as well as addition of rVEGFR1. In SKOV3 and HeyA8 cell lines, the cell numbers were significantly lower in the recombinant VEGFR1 groups compared to the control groups. *P < 0.05 compared to the pLV-EGFP group. P values are as follows; *1:P = 0.024, *2:P = 0.025, *3:P = 0.018, *4:P = 6.8 × 10−4, *5:P = 0.022, *6:P = 2.1 × 10−3, *7:P = 5.3 × 10−3, *8:P = 0.030, *9:P = 0.039, *10:P = 0.041, *11:P = 0.033, *12:P = 0.013.
