Figure 1 | Scientific Reports

Figure 1

From: TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis

Figure 1

Effects of estradiol (E2) and progesterone (P4) on β-cell survival and function.

MIN6 cells were plated at 5 × 105 cells per well in 6-well plates and treated with different combination of E2 (10 or 100 nM), P4 (1 μM), progesterone receptor antagonist (RU486 40 uM) and estradiol receptor antagonist (ICI182780 10 uM) for 24 h. The concentrations of hormones are in the physiological ranges. (A) Viable cells. (B,C) Basal and stimulated insulin/proinsulin secretions (normalized to viable cell numbers). (D,E) Stimulatory indexes. (F) Proinsulin-to-insulin ratio. *P < 0.05 vs. blank control; #P < 0.05 vs. E2 (100 nM) plus P4 (1 μM).

Back to article page