Figure 1 | Scientific Reports

Figure 1

From: Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen

Figure 1

Hepatic interferon responses can be detected in HBV-s-mut but not HBV-s-rec mice.

Two-month-old transgenic HBV mice (HBV-s-mut, HBV-s-rec) and wild type littermates (WT) and were put to death, RNA from liver tissue was extracted and changes in gene expression of Ifnb1, Isg15, Ifit1 (A) and Il1b, Il6, Il10 (B) were determined by quantitative RT-PCR. Copy numbers were normalized to 100,000 copies of GAPDH (mean values ± SEM). Group size n = 4; ***p < 0.001

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