Figure 3: Features of GBM in in vitro biomimetic microenvironment platform.
From: Strategies of Mesenchymal Invasion of Patient-derived Brain Tumors: Microenvironmental Adaptation
(A) The culture process of three-dimensional GBM tumorsphere (TS) in in vitro biomimetic microenvironment platform. (B) Morphological characteristics of GBM TSs within the in vitro biomimetic microenvironment platform. Fluorescent images of TSs along the electrospun fiber. (Blue: nucleus, Green: cytosol, Red: F-actin). (C) Relative expression of HA metabolic genes: synthetic genes (HAS) and enzymatic genes (HYAL) (n = 5~6; Asterisks indicate a significant difference by student’s t-test, **p < 0.001; no sign for Non-significant difference).
