Table 2 Association of two SNPs with Behçet’s Disease.

From: Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population

Gene

SNP

Stage

Genotype/Allele

BD

Controls

P Value

Pc Value

OR (95% CI)

N

%

N

%

ITGAX (CD11c)

rs2929

First

AA

15

3.8

23

3.8

0.986

NS

1.01 (0.52–1.95)

AG

82

21.0

193

32.0

1.453 × 10−4

0.019

0.56 (0.42–0.76)

GG

294

75.2

387

64.2

2.606 × 10−4

0.034

1.69 (1.27–2.25)

G

670

85.7

967

80.2

0.002

NS

1.48 (1.16–1.89)

Second

AA

12

1.6

40

2.7

0.107

NS

0.59 (0.31–1.13)

AG

180

23.7

470

31.3

1.974 × 10−4

1.184 × 10−3

0.69 (0.56–0.84)

GG

566

74.7

994

66.1

3.135 × 10−5

1.881 × 10−4

1.51 (1.24–1.84)

G

1312

86.5

2458

81.7

3.904 × 10−5

7.808 × 10−5

1.44 (1.21–1.71)

Combined

AA

27

2.3

63

3.0

0.287

NS

0.78 (0.50–1.23)

AG

262

22.8

663

31.5

1.618 × 10−7

2.087 × 10−5

0.64 (0.55–0.76)

GG

860

74.8

1381

65.5

4.320 × 10−8

5.573 × 10−6

1.56 (1.33–1.84)

G

1982

86.2

3425

81.3

3.252 × 10−7

1.398 × 10−5

1.45 (1.25–1.67)

CD6

rs11230563

First

CC

252

64.5

468

77.6

5.721 × 10−6

7.380 × 10−4

0.52 (0.39–0.69)

CT

128

32.7

121

20.1

6.685 × 10−6

8.624 × 10−4

1.94 (1.45–2.59)

TT

11

2.8

14

2.3

0.629

NS

1.22 (0.55–2.71)

C

632

80.8

1057

87.6

3.189 × 10−5

1.371 × 10−3

0.59 (0.46–0.76)

Second

CC

501

66.1

1137

75.6

1.811 × 10−6

1.087 × 10−5

0.63 (0.52–0.76)

CT

238

31.4

349

23.2

2.714 × 10−5

1.628 × 10−4

1.52 (1.25–1.84)

TT

19

2.5

18

1.2

0.020

NS

2.12 (1.11–4.07)

C

1240

81.8

2623

87.2

1.176 × 10−6

2.352 × 10−5

0.66 (0.56–0.78)

combined

CC

753

65.5

1605

76.2

8.501 × 10−11

1.097 × 10−8

0.60 (0.51–0.70)

CT

366

31.9

470

22.3

2.532 × 10−9

3.266 × 10−7

1.63 (1.39–1.91)

TT

30

2.6

32

1.5

0.029

NS

1.74 (1.05–2.88)

C

1872

81.5

3680

87.3

1.766 × 10−10

7.594 × 10−9

0.64 (0.56–0.73)

  1. Pc, Bonferroni corrected p value; NS, not significant; SNP, single nucleotide polymorphism.
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