Figure 2: Pedigrees of crosses between Setdb1MD13 or Trim28MD9 and mice carrying the Avy allele. | Scientific Reports

Figure 2: Pedigrees of crosses between Setdb1MD13 or Trim28MD9 and mice carrying the Avy allele.

From: Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype

Figure 2

(a) Pedigree produced from a Setdb1MD13/+ sire and pseudoagouti (Avy) dam. Wild type (WT) offspring from Setdb1MD13/+ sires showed a significant increase (Chi-square test: P < 0.001) in the proportion of animals with yellow coats when compared with WT offspring from WT sires. Offspring heterozygous for Setdb1MD13 demonstrated a significant shift in penetrance toward yellow when compared to WT littermates (Chi-square test: P < 0.02). (b) Pedigree produced from a Trim28MD9/+ sire and pseudoagouti (Avy) dam. Trim28MD9 heterozygotes exhibited a significant shift in penetrance toward yellow when compared with WT littermates (Chi-square test: P < 0.05). (c) Pedigree produced from a pseudoagouti (Avy) sire and Setdb1MD13/+ dam. Offspring showed no shift in penetrance at Avy. For all crosses data were produced from at least five different mating pairs. Offspring not carrying the Avy allele have been omitted.

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