Table 1 Effect of parental haploinsufficiency of epigenetic modifiers on expression of Avyin offspring.

From: Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype

 

Mutant sire (Maternally derived Avy allele)

Mutant dam (Paternally derived Avy allele)

References

Effect on wild-type offspring

Effect on mutant offspring

Effect on wild-type offspring

Effect on mutant offspring

Dnmt1 MD2

Yes

Yes

No

Yes*

Blewitt et al.33, Chong et al.24 and data not shown

Snf2h MD4

Yes

Yes

n.d.

n.d.

Chong et al.24

Rlf  MD8

n.d.

n.d.

No

Yes

Daxinger et al.32

Smchd1 MD1

No

Yes

No

No

Blewitt et al.33

Trim28 MD9

No

Yes

n.d.

n.d.

This study

Setdb1 MD13

Yes

Yes

No

No

This study

  1. *Female specific effect.
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