Figure 3

(A–C) Drug-time curves of propranolol, thiopentone and pentobarbital in the medium cycle in the fourth spacer. (D) The distribution of pentobarbital and propranolol in the heart, lung and adipose tissues. Pentobarbital was not detected in heart tissues in any of the three independent experiments. (E) The inhibition of MCF-7 cell proliferation in response to cyclophosphamide (CTX), taxol and 5-fuorouracil on the chip and in 96-well plate during 72 h of culture. (F) The alanine aminotransferase (ALT) values of paracetamol, propranolol, cyclophosphamide, taxol and 5-fuorouracil. N = 3. Error bars represent the standard error of the mean (SEM) of three independents experiments. Two-tailed significance was set to *p < 0.05 and **p < 0.001.