Figure 4
Thrombin-induced pulmonary edema correlates with presence of thromboembolism.
(a) In vivo 
weighted MRI of the thorax before (left) and after (right) intravenous injection of human thrombin. Green dotted line indicates area of 
signal increase. Compared to saline injection, injection of human thrombin induced significant focal signal increase in 
weighted images (saline n = 4-vs. thrombin n = 12 mice per group, p < 0.05, Mann-Whitney U Test). (b) Immunohistochemistry staining for platelet CD41 (20x magnification) in thrombin-induced pulmonary embolism (PE). Bar indicates 100 μm. Relevant pulmonary embolism can be found in areas with increased 
, but is absent in tissue without 
signal increase. Data are shown as mean ± s.e.m.
