Figure 6: Cellular uptake efficacy of alkyl chain-modified dendrimer/siRNA complexes in HeLa-luc cells.
From: Screening of efficient siRNA carriers in a library of surface-engineered dendrimers
(a) At optimal weight ratios as shown in Fig. 5a. The optimal weight ratios for A3-1, A4-1, A5-2, A6-3, A7-3, A9-3, A10-3 and A11-3 are 12, 20, 10, 2, 3, 4, 4 and 4, respectively. (b) At an equal polymer molar concentration of 175 nM (175 nM is the optimal concentration for lauric acid-modified G5 PAMAM dendrimer). 0.5 μg siLuc is used for each well and the cellular uptake experiments were conducted for 2 h. Error bars in a-b represent the s.e. (n = 3).
