Figure 5: Effect of misTTR on TTR fibrillogenesis. | Scientific Reports

Figure 5: Effect of misTTR on TTR fibrillogenesis.

From: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Figure 5

(A) Time course of TTR fibril formation monitored by turbidity (3.6μM, 37 °C, pH 4.5). Substoichiometric amounts of misTTR were added at time 0 and after 30 hours to determine effect on TTR fibrillization process. (B) Dose dependent inhibition of TTR fibril formation by misTTR after 72 h. ThT emission peak was integrated from 475 nm to 495 nm and plotted versus antibody concentration (IC50 = 9.08 ± 0.32 nM).

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