Figure 6: Correlation of solvent excluded surface area of tetrameric and monomeric TTR with peptide inhibitor segments and the misTTR epitope. | Scientific Reports

Figure 6: Correlation of solvent excluded surface area of tetrameric and monomeric TTR with peptide inhibitor segments and the misTTR epitope.

From: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Figure 6

The solvent excluded surface area (SES) of monomeric and the tetramer subunit form of TTR was calculated using Chimera molecular visualization program47 using the coordinate file 3KGU. The peptide inhibitors are those developed by Saelices et al.43. Note the correlation of the locations of the misTTR epitope and inhibitor peptides with changes in SES associated with monomerization of TTR.

Back to article page