Table 3 Stage 2 analysis showed the association of SNPs in (s)ANK1 for T2D development and the levels of HbA1c, Hb and fasting glucose.
T2D Development a | HbA1c (%) adjusted for glucose, sex, age b | Hb (g/L) adjusted for sex, age b | Fasting glucose (mmol/L) adjusted for sex, age b | |
|---|---|---|---|---|
SNP (Effect/other) | ||||
rs508419 (C/T) | 1.531 (1.215–1.930) 2.85 × 10−4 | 0.069 (0.008) 0.115 | 0.005 (0.001) 0.898 | −0.015 (0.005) 0.696 |
rs515071 (C/T) | 1.468 (1.199–1.798) 1.86 × 10−4 | 0.049 (0.008) 0.261 | 0.047 (0.001) 0.263 | 0.008 (0.006) 0.828 |
rs516946 (C/T) | 1.495 (1.187–1.882) 5.88 × 10−4 | 0.071 (0.007) 0.106 | 0.000 (0.001) 0.996 | −0.005 (0.005) 0.893 |
CCC | 1.477 (1.203–1.814) 1.87 × 10−4 | 1.292 (0.930 ~ 1.794) 0.125 | 0.711 (0.491 ~ 1.029) 0.069 | 0.817 (0.578–1.154) 0.251 |
rs4737009 (A/G) | − | −0.031 (0.012) 0.488 | 0.025 (0.001) 0.473 | 0.026 (0.008) 0.495 |
rs6474359 (C/T) | − | −0.001 (0.005) 0.978 | −0.059 (0.001) 0.161 | − 0.027 (0.004) 0.481 |
