Figure 1: Mmp11-Tg mice metabolic analyses.
From: Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch
(a) Upper left panel, scheme of the transgene construct. Lower left panel, Western blot showing MMP11 expression in skin protein extracts from 12-week-old WT and Mmp11-Tg mice (n = 3/group); right panel, qRT-PCR analysis showing the robust increase in Mmp11 mRNA expression in Mmp11-Tg mice compared to controls (n = 5/group); (b) Body weight progression in 8- and 40-week-old Mmp11-Tg and WT mice (n = 9/group); (c) IPGTT and IPIST analyses and AUC in Mmp11-Tg and WT mice under normal diet conditions; (d) Circulating adiponectin and leptin levels in Mmp11-Tg and WT mice (n = 8/group); (e) HE staining of gonadal WAT, mammary gland WAT and BAT histological sections from Mmp11-Tg and WT mice. The WAT of Mmp11-Tg mice displayed areas of multilocular brown adipocyte-like cells compared to WT counterparts. The BAT of Mmp11-Tg mice accumulates smaller and less lipid droplets compared to WT animals; (f) Expression profile of genes involved in adipogenesis (n = 6–7/group).
