Table 2 Confirmation of NAI susceptibility of NanA constructs by the chemiluminescence-based NA inhibition assay.
From: Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility
NanA | 50% inhibitory concentration (μM)a | |
|---|---|---|
Oseltamivir | DANA | |
8919-LC | 0.34 ± 0.04 | 1.06 ± 0.44 |
20566-LC | 0.34 ± 0.03 | 3.80 ± 0.50 |
20566-CC | 0.36 ± 0.05 | 2.35 ± 0.16 |
20566-CC-KGV | 0.39 ± 0.15 | 4.56 ± 0.71 |
20566-CC-RAV | 1.27 ± 0.25 | 0.92 ± 0.71 |
9400-LC | 0.11 ± 0.01 | 10.06 ± 5.77 |
9400-CC | 0.12 ± 0.01 | 4.95 ± 2.12 |
